It is the attack of the burning skin pain yet again. This time my lower back. I cannot stress how insanely painful this is. Just the lightest of touches. Just clothing brushing against my skin. It is just like the nerves are on fire. It started this morning when I woke up in a very specific spot on my lower back and then it just spread as the day went on. Down my thigh on that side as well.
“Allodynia involves a noxious response to an innocuous stimulus (think putting on a shirt with a severe sunburn). Because the stimulus is innocuous, and generally of the mechanical variety, it could be carried by rapidly adapting mechanotransducers or by sensitized nociceptors. These two possibilities have been the focus of decades of research both in humans and in animals. While there is evidence that the information can be carried by sensitized nociceptors this is quite controversial. Our current understanding of allodynia suggests that nociceptor mechanical thresholds do not change enough for them to carry information concerning light touch, brush or gentle vibration in conditions where allodynia is present. Rather, it appears that rapidly adapting mechanotransducers (or A-beta fibers) continue to be the sole carrier of this information in conditions where allodynia is present. The change that causes allodynia occurs in the spinal cord. Through an unknown process, A-beta-fibers gain access to the nociceptive channel. In normal conditions A-beta-fibers cannot activate dorsal horn neurons that respond only to painful stimulation. In allodynic conditons, these same neurons begin to receive input from A-beta-fibers. This allows for A-beta-mediated information to gain access to the nociceptive channel thereby stimulating the perception of pain in the brain. Because allodynia can occur rapidly it is unlikely that this change is mediated by a physical change in the connections of neurons in the dorsal horn (although this may occur over the longer term). Rather, it appears that there are changes in the neurochemistry of the “gate” such that inhibitory neurotransmission can switch to excitation. Because GABA (the primary inhibitory neurotransmitter in the brain) can switch from inhibition to excitation (or vice-a-versa) in certain conditions (like epilepsy and during early neural development) much current focus is on the role of GABA in allodynia.”(JuniorProf)
Maybe I will not be so way of taking that slow release tramadol if it can help with this allodynia outbreaks I am getting. Right now my tramacet is the only thing making the pain bearable enough to sleep with. https://w.atcontent.com/-/1uTQhq1D4GY/nikki.albert/0i7FDQRfguS.text/Panel/Autocheck