botox migraine research Uncategorized

Migraine Botox study

migraine botox study.png

OnabotulinumtoxinA   (BOTOX) was shown to have better results with chronic migraine people who (in recent study published in the European Journal of Neurology):

  • Have unilateral pain vs bilateral pain.
  • Fewer disabilities days per month
  • Milder headache
  • Started 12 months of symptom onset

So, not, not, not, not me I guess.

The study involved 725 subjects with chronic migraine. Those that had failed greater than 2 preventative treatments. They received it every 12 weeks for a year. They recorded intensity, quantity, and duration in a diary that was collected at 3 months and then again at 12 months.

In 79.3 subjects pain was reduced by 50% after a year. Migraines, analgesics, ER visits, headache intensity and sick days all reduced as well.

When compared to non-responders the factors



When onabotulinumtoxinA responders (n=575) were compared with nonresponders (n=150), the following factors were associated with response to onabotulinumtoxinA: unilateral pain (P =.02), fewer disability days per month at baseline (P =.001), lower headache intensity at baseline (P =.02), and initiation of treatment within 12 months of chronic migraine onset (P =.045). Most patients (94.9%) reported no adverse events at 12-month follow-up. Clinical Pain Advisor


So this doesn’t bode well for my 3rd round which I was hoping might be the one that works, eh? But we shall see. You never know. A minor reduction would still be a reduction.



Domínguez C, Pozo-Rosich P, Torres-Ferrús M. OnabotuliumtoxinA in chronic migraine: predictors of response. A prospective multicentre descriptive study


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