migraine botox study.png

OnabotulinumtoxinA   (BOTOX) was shown to have better results with chronic migraine people who (in recent study published in the European Journal of Neurology):

  • Have unilateral pain vs bilateral pain.
  • Fewer disabilities days per month
  • Milder headache
  • Started 12 months of symptom onset

So, not, not, not, not me I guess.

The study involved 725 subjects with chronic migraine. Those that had failed greater than 2 preventative treatments. They received it every 12 weeks for a year. They recorded intensity, quantity, and duration in a diary that was collected at 3 months and then again at 12 months.

In 79.3 subjects pain was reduced by 50% after a year. Migraines, analgesics, ER visits, headache intensity and sick days all reduced as well.

When compared to non-responders the factors



When onabotulinumtoxinA responders (n=575) were compared with nonresponders (n=150), the following factors were associated with response to onabotulinumtoxinA: unilateral pain (P =.02), fewer disability days per month at baseline (P =.001), lower headache intensity at baseline (P =.02), and initiation of treatment within 12 months of chronic migraine onset (P =.045). Most patients (94.9%) reported no adverse events at 12-month follow-up. Clinical Pain Advisor


So this doesn’t bode well for my 3rd round which I was hoping might be the one that works, eh? But we shall see. You never know. A minor reduction would still be a reduction.



Domínguez C, Pozo-Rosich P, Torres-Ferrús M. OnabotuliumtoxinA in chronic migraine: predictors of response. A prospective multicentre descriptive study

3 thoughts on “Migraine Botox study

  1. I’ve done Botox three times and the result has been minimal. Yes, any pain reduction is a win, but for me, the tightness it caused in my forehead was a trigger. We’ve just moved (again!) and I’m going to appeal to the new (military) neuro docs to try it in my shoulders and occipitals. I sure hope the result is more positive!

    Liked by 1 person

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