Aimovig is one of the brand spanking new migraine preventatives out there that blogs CGRP proteins in the brain.

he research suggests targeting calcitonin gene-related peptide (CGRP), a protein that helps with triggering, sending, and heightening sensitivity to the migraine pain, can help improve migraine intensity and frequency in migraineurs when blocked. CGRP is released during a migraine. It is a strong vasodilator of cerebral arteries. The serum CGRP levels are elevated in migraine and persistently in chronic migraines. CGRP basically binds to receptors that activate and cause symptoms of migraines like vasodilation, inflammation and pain. ScienceMag

The hope of aimovig for migraine prevention- first dose

I have been excited to try on in this class since the research came out about them. Look at my article on Aimovigto see the success percentages, which are pretty cool for chronic migraine.

aimovig

This is the 140 mg injector pen before use. When you get it, immediately put in the fridge. When you want to use it take it out and let it sit for half an hour.

It is easy to use the Aimovig injector which is used 1 time per month

  1. It will tell you to check the pen for any damage on the window for any inconsistencies in the liquid.
  2. Wash your hands with soap
  3. Wipe the area with an alcohol rub
  4. I used on the thigh, where you stretch the area out. On the stomach, you would pinch the area. On the arm, you would get someone else to inject, so the angle can be as required at 90 degrees.
  5. Pull out the plug straight with no twisting.
  6. Press to the skin and hit button, and release.
  7. It injects
  8. And then you can tell it is done because the window is yellow. Then dispose of in the biohazard bin provided.

aimovigd

As you can see after use the window is clearly yellow showing the entire dose was injected.

And behind in the photo you can see I am going to dispose of it in the bin they provided.

Easy peasy sandwich cheesy.

The potential for migraine treatment

The potential is a 50% reduction in migraine attacks. And that sounds like a Sweet deal to me.

Another perk is that the listed side effects are very short. Side injection irritation, itching, or constipation.

My injection site is slightly red as of today, a day later, not bad at all really. (Imitrex injecter pens left nasty bruises)

Hope for migraine prevention

One does want to hope. And I do hope. I was waiting for this delivery of Aimovig like a damn Christmas present… that is how eager I am to try it. So I have a boatload of hope. I am excited about the potential.

But I cannot have too much hope. I have been disappointed so very many times. I am unresponsive to medication (that is how they labelled me). In other words, no preventative has ever worked for my migraine disease. Ever. But this is an entirely new class designed specifically for migraine disease … and hope springs anew. I do not want to crash if it fails though. So I want reasonable expectations.

Nevertheless, if it fails, and it might… there are 3 others to try. 1 of which is now FDA approved in Canada already. We have Emgality here now as well. Here is the list of ones designed for migraine:

  • Aimovig (erenumab-aooe)
  • Ajovy (fremanezumab)
  • Emgality (galcanezumab-gnlm)
  • Eptinezumab

And some of them work differently than the others. From what I remember, some bind with CGRP and some block it… so that means if the one type does not work for you maybe the other type will.

Just saying… it is the new hope for people with migraine disease.

The next day

I do have a slight red mark at the injection site about an inch in circumference. It isn’t itchy or sore or anything.

I am drained today. High fatigue and intense sleepiness. Laid on the couch all day and slept a whole lot. Couldn’t really even sit up and go on the laptop… too exhausted. And that could be a side effect of getting used to the drug in my system… so a short duration one. Or it could just be that my vertigo, which has been acting up this last week, is just a really bad day. We shall see how tomorrow goes. Sometimes though new medication pack a powerful punch and can take a few days to adjust to them… so it very well could be that.

Other than that… I had No migraine ALL day. I had like a headache of a pending migraine… that never developed into a migraine. So a weird sensation. Like being in the prodrome all day but never hitting the headache stage. So strange. But no migraine pain at all. I will take this as a good sign. I hope tomorrow goes good as well! I didn’t anticipate a quick response but maybe just a lucky day? Or I am responding Very well. We shall see!

Migrelief - Outsmart Your Migraines

See more on CGRP research

Aimovig

CGRP: The Hope

CGRP: The new frontier in migraine prevention

What is on the horizon with migraine- Dr. Goadsby

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